Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 3/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.41 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | IL1B | P01584 | 1/20 | 0.41 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31033662 | 1.00 | CRBN (0.42) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL26095149 | 0.90 | CRBN (0.42) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL30351467 | 0.89 | CRBN (0.43) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL26094744 | 0.89 | CRBN (0.43) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL31033598 | 0.88 | CRBN (0.42) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL26090226 | 0.87 | CRBN (0.45) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL31034332 | 0.87 | CRBN (0.45) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL26448198 | 0.85 | CRBN (0.46) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL31033651 | 0.85 | CRBN (0.48) | CRBNIKZF1TNFDDB1IKZF3 | |
| SCHEMBL26450483 | 0.85 | CRBN (0.48) | CRBNIKZF1TNFDDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023066350-A1 | CRBN E3 LIGASE LIGAND COMPOUND, PROTEIN DEGRADING AGENT DEVELOPED ON THE BASIS OF LIGAND COMPOUND, AND THEIR APPLICATIONS | 标新生物医药科技(上海)有限公司 | 2023-04-27 | — | — | WO | claimed |
| CN-116003418-A | CRBN E3 ligase ligand compound, protein degradation agent developed based on ligand compound and application thereof | 标新生物医药科技(上海)有限公司 | 2023-04-25 | — | — | CN | claimed |