Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.55 |
| ▸ | GPR4 | P46093 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30393009 | 0.95 | CRBN (0.51) | CRBNDDB1GPR4KCNH2NAAA | |
| SCHEMBL26102089 | 0.93 | CRBN (0.61) | CRBNDDB1GPR4KCNH2GSPT1 | |
| Trifluoroacetic Acid SCHEMBL30392716 | 0.89 | CRBN (0.55) | CRBNDDB1GPR4KCNH2GSPT1 | |
| SCHEMBL26100659 | 0.87 | CRBN (0.51) | CRBNDDB1GPR4 | |
| SCHEMBL23540585 | 0.87 | CRBN (0.62) | CRBNDDB1GSPT1HRH3 | |
| SCHEMBL23540810 | 0.82 | CRBN (0.56) | CRBNDDB1GSPT1HRH3 | |
| SCHEMBL26100060 | 0.82 | CRBN (0.58) | CRBNDDB1 | |
| SCHEMBL26102995 | 0.82 | CRBN (0.54) | CRBNDDB1HRH3 | |
| SCHEMBL30289171 | 0.81 | CRBN (0.55) | CRBNDDB1GSPT1TNKSPARP2 | |
| SCHEMBL23541139 | 0.81 | DDB1 (0.64) | CRBNDDB1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250051338-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2025-02-13 | — | — | US | disclosed |
| CN-119013277-A | TYK2 degrading agent and application thereof | 凯麦拉医疗公司 | 2024-11-22 | — | — | CN | disclosed |
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250051338-A1 | TYK2 DEGRADERS AND USES THEREOF | TYK2, DYRK2, DYRK1A | CRBN 111/4885DDB1 2403/4885GPR4 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.