Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 5/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26098589 | 0.90 | TYK2 (0.39) | TYK2PDE4DAURKAMAPT | |
| SCHEMBL30392502 | 0.90 | TYK2 (0.39) | TYK2PDE4DAURKAMAPT | |
| SCHEMBL30392341 | 0.90 | TYK2 (0.39) | TYK2PDE4DAURKAMAPT | |
| SCHEMBL26099037 | 0.90 | TYK2 (0.39) | TYK2PDE4DAURKAMAPT | |
| SCHEMBL26099068 | 0.90 | TYK2 (0.44) | TYK2PDE4D | |
| SCHEMBL30392726 | 0.88 | TYK2 (0.40) | TYK2PDE4DAURKAMAPT | |
| SCHEMBL26102885 | 0.88 | TYK2 (0.40) | TYK2PDE4DAURKAMAPT | |
| SCHEMBL30392536 | 0.85 | TYK2 (0.38) | TYK2PDE4DAURKA | |
| SCHEMBL26097861 | 0.85 | TYK2 (0.38) | TYK2PDE4DAURKA | |
| SCHEMBL30392501 | 0.83 | TYK2 (0.41) | TYK2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |