Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 5/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7644358 | 0.81 | HDAC6 (0.54) | HDAC6ALDH1A1KDM4EKMT2AFPR2 | |
| SCHEMBL16137958 | 0.80 | HDAC6 (0.53) | HDAC6ALDH1A1KDM4EKMT2AFPR2 | |
| SCHEMBL20592531 | 0.79 | HDAC6 (0.52) | HDAC6ALDH1A1KDM4EKMT2AFPR2 | |
| SCHEMBL21488666 | 0.78 | HDAC6 (0.51) | HDAC6ALDH1A1KDM4EKMT2AFPR2 | |
| SCHEMBL28254025 | 0.75 | KDM4E (0.50) | HDAC6ALDH1A1KDM4EKMT2APOLB | |
| SCHEMBL7638300 | 0.74 | HDAC6 (0.47) | HDAC6ALDH1A1KDM4E | |
| SCHEMBL7643485 | 0.73 | HDAC6 (0.52) | HDAC6ALDH1A1KDM4EGPR119ELANE | |
| SCHEMBL7641512 | 0.73 | MAPK14 (0.62) | — | |
| SCHEMBL16753833 | 0.72 | HDAC6 (0.48) | HDAC6ALDH1A1KDM4E | |
| SCHEMBL23397121 | 0.70 | KMT2A (0.46) | HDAC6ALDH1A1KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530499-B2 | Glucokinase activators | TAKEDA SAN DIEGO, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530499-B2 | Glucokinase activators | TAKEDA SAN DIEGO, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20120252814-A1 | Glucokinase Activators | TAKEDA CALIFORNIA, INC. (US) | 2012-10-04 | — | — | US | disclosed |
| US-20120252814-A1 | Glucokinase Activators | TAKEDA CALIFORNIA, INC. (US) | 2012-10-04 | — | — | US | disclosed |
| US-8163779-B2 | Glucokinase activators | TAKEDA SAN DIEGO, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163779-B2 | Glucokinase activators | TAKEDA SAN DIEGO, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090105255-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2009-04-23 | — | — | US | disclosed |
| US-20090105255-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2009-04-23 | — | — | US | disclosed |
| WO-2008079787-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252814-A1 | Glucokinase Activators | GCK, GCKR, GALK1 | HDAC6 1798/4885ALDH1A1 1177/4885KDM4E 2490/4885 |
| US-20090105255-A1 | GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | HDAC6 1798/4885ALDH1A1 1177/4885KDM4E 2490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.