Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 16/20 | 0.67 |
| ▸ | DYRK2 | Q92630 | 16/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 14/20 | 0.67 |
| ▸ | PIM1 | P11309 | 10/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.67 |
| ▸ | CLK1 | P49759 | 6/20 | 0.67 |
| ▸ | CLK2 | P49760 | 6/20 | 0.67 |
| ▸ | CSNK2A2 | P19784 | 6/20 | 0.67 |
| ▸ | CSNK2B | P67870 | 6/20 | 0.67 |
| ▸ | CSNK2A1 | P68400 | 6/20 | 0.67 |
| ▸ | CSNK2A3 | Q8NEV1 | 6/20 | 0.67 |
| ▸ | CLK3 | P49761 | 5/20 | 0.67 |
| ▸ | GSK3B | P49841 | 5/20 | 0.67 |
| ▸ | DYRK4 | Q9NR20 | 2/20 | 0.64 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26093157 | 0.84 | DYRK1B (0.51) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL30494279 | 0.84 | DYRK1B (0.51) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL26093147 | 0.84 | DYRK2 (0.67) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL26093411 | 0.82 | DYRK2 (0.69) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL30494198 | 0.82 | DYRK2 (0.69) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL28843038 | 0.82 | DYRK1A (0.64) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL29899954 | 0.82 | DYRK1A (0.64) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL26103696 | 0.82 | DYRK1A (0.64) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL30363298 | 0.81 | DYRK1A (0.75) | DYRK1ADYRK1BDYRK2DYRK3PIM1 | |
| SCHEMBL26093954 | 0.81 | DYRK1A (0.75) | DYRK1ADYRK1BDYRK2DYRK3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | claimed |
| WO-2023072966-A1 | IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-05-04 | — | — | WO | disclosed |