Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30392635 | 1.00 | TNIK (0.35) | TNIKAURKAPDE1BNPC1RAB9A | |
| SCHEMBL30392226 | 0.92 | MAPT (0.35) | TNIKAURKAPDE1BPIM3 | |
| SCHEMBL26098627 | 0.92 | MAPT (0.35) | TNIKAURKAPDE1BPIM3 | |
| SCHEMBL30392428 | 0.90 | TYK2 (0.34) | TNIKAURKAPDE1BNPC1RAB9A | |
| SCHEMBL26098437 | 0.90 | TYK2 (0.34) | TNIKAURKAPDE1BNPC1RAB9A | |
| SCHEMBL26100166 | 0.88 | TNIK (0.33) | TNIKPDE1BMDM2TYK2PDE4D | |
| SCHEMBL26101621 | 0.81 | MAPT (0.32) | TNIKMDM2TYK2PDE4DPIM3 | |
| SCHEMBL26510925 | 0.80 | TYK2 (0.37) | AURKAPDE1BNPC1RAB9ATYK2 | |
| Potassium SCHEMBL30392578 | 0.79 | TYK2 (0.37) | AURKAPDE1BNPC1RAB9ATYK2 | |
| SCHEMBL26099790 | 0.79 | TYK2 (0.37) | AURKAPDE1BNPC1RAB9ATYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |