Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 14/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 14/20 | 0.46 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 3/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22835368 | 0.92 | DDB1 (0.48) | DDB1CRBNSPRAAK1 | |
| SCHEMBL25339464 | 0.87 | DDB1 (0.44) | DDB1CRBNSPR | |
| SCHEMBL26101821 | 0.83 | CRBN (0.50) | DDB1CRBNKIF18ARETAAK1 | |
| SCHEMBL25123032 | 0.83 | DDB1 (0.46) | DDB1CRBNSPR | |
| SCHEMBL21997064 | 0.83 | DDB1 (0.47) | DDB1CRBNSPR | |
| SCHEMBL21997298 | 0.82 | DDB1 (0.46) | DDB1CRBNSPR | |
| SCHEMBL21997696 | 0.82 | DDB1 (0.46) | DDB1CRBNSPR | |
| SCHEMBL21070402 | 0.82 | DDB1 (0.46) | DDB1CRBNSPR | |
| SCHEMBL24607721 | 0.82 | DDB1 (0.52) | DDB1CRBN | |
| SCHEMBL31726723 | 0.82 | DDB1 (0.52) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250051338-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2025-02-13 | — | — | US | disclosed |
| CN-119013277-A | TYK2 degrading agent and application thereof | 凯麦拉医疗公司 | 2024-11-22 | — | — | CN | disclosed |
| EP-4423086-A1 | TYK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250051338-A1 | TYK2 DEGRADERS AND USES THEREOF | TYK2, DYRK2, DYRK1A | DDB1 2403/4885CRBN 111/4885KIF18A 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.