Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26101088 | 0.91 | TYK2 (0.36) | TYK2PDE4DJAK1JAK2 | |
| SCHEMBL26101963 | 0.85 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL30392588 | 0.85 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL31218902 | 0.81 | TYK2 (0.33) | TYK2JAK1 | |
| SCHEMBL26099044 | 0.78 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL30392440 | 0.78 | TYK2 (0.49) | TYK2PDE4D | |
| SCHEMBL26100791 | 0.76 | TYK2 (0.35) | TYK2PDE4DJAK1JAK2 | |
| SCHEMBL31218679 | 0.73 | TYK2 (0.32) | TYK2JAK1 | |
| SCHEMBL30391456 | 0.73 | TYK2 (0.37) | TYK2PDE4DJAK1 | |
| SCHEMBL26101583 | 0.73 | TYK2 (0.37) | TYK2PDE4DJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |