Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | GSPT1 | P15170 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100871 | 1.00 | CRBN (0.60) | CRBNDDB1PRKD3PRKCGPRKCB | |
| SCHEMBL26102201 | 0.99 | CRBN (0.61) | CRBNDDB1PRKD3PRKCGPRKCB | |
| SCHEMBL21070551 | 0.95 | CRBN (0.56) | CRBNDDB1GSPT1 | |
| SCHEMBL21070813 | 0.93 | CRBN (0.57) | CRBNDDB1GSPT1 | |
| SCHEMBL21069635 | 0.92 | CRBN (0.56) | CRBNDDB1GSPT1 | |
| SCHEMBL21071732 | 0.92 | CRBN (0.56) | CRBNDDB1GSPT1 | |
| SCHEMBL21071299 | 0.91 | CRBN (0.57) | CRBNDDB1GSPT1 | |
| SCHEMBL21071322 | 0.90 | CRBN (0.56) | CRBNDDB1GSPT1 | |
| SCHEMBL21070938 | 0.90 | CRBN (0.56) | CRBNDDB1GSPT1 | |
| SCHEMBL30304459 | 0.85 | DDB1 (0.58) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076161-A1 | TYK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |