SCHEMBL26107325

SCHEMBL26107325

Cc1cc(C2=CC(C(=O)OC(C)(C)C)CNC2)cn2c(=O)c(-c3cccc(C4(c5nncn5C)CC(C)C4)c3)cnc12

nearest known ligand 0.50

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CBLB Q13191 20/20 0.50
CBL P22681 19/20 0.47
CBLC Q9ULV8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26107322 0.83 CBLB (0.49) CBLBCBLCBLC
SCHEMBL26101931 0.78 CBLB (0.58) CBLBCBLCBLC
SCHEMBL29254085 0.78 CBLB (0.50) CBLBCBLCBLC
SCHEMBL26106350 0.77 CBLB (0.54) CBLBCBLCBLC
SCHEMBL31251410 0.73 CBLB (0.72) CBLBCBLCBLC
SCHEMBL26481375 0.73 CBLB (0.64) CBLBCBLCBLC
SCHEMBL31251296 0.71 CBLB (0.76) CBLBCBLCBLC
SCHEMBL26480785 0.70 CBLB (0.66) CBLBCBLCBLC
SCHEMBL30938785 0.70 CBLB (0.53) CBLBCBLCBLC
SCHEMBL26481490 0.70 CBLB (0.53) CBLBCBLCBLC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118139856-A Parallel-ring compounds as Cbl-b inhibitors 海南先声再明医药股份有限公司 2024-06-04 CN disclosed
WO-2023072273-A1 POLYCYCLIC COMPOUND AS CBL-B INHIBITOR 先声再明医药有限公司 2023-05-04 WO disclosed