Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 16/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30588398 | 0.99 | AR (0.38) | ARSLC22A12ALDH1A1KDM4EPOLB | |
| Hydrochloric Acid SCHEMBL26116093 | 0.99 | AR (0.38) | ARSLC22A12ALDH1A1KDM4EPOLB | |
| SCHEMBL24267412 | 0.88 | AR (0.40) | ARSLC22A12ALDH1A1KDM4EPOLB | |
| SCHEMBL24267288 | 0.81 | SLC22A12 (0.35) | ARSLC22A12ALDH1A1KDM4EPOLB | |
| SCHEMBL26111679 | 0.79 | AR (0.55) | AR | |
| SCHEMBL26111676 | 0.79 | AR (0.55) | AR | |
| Hydrochloric Acid SCHEMBL30588175 | 0.79 | AR (0.41) | AR | |
| Hydrochloric Acid SCHEMBL26112163 | 0.79 | AR (0.41) | AR | |
| SCHEMBL31565320 | 0.78 | AR (0.39) | ARSLC22A12 | |
| SCHEMBL31566168 | 0.76 | AR (0.52) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023180388-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERIVATIVES AS DEGRONS IN PROTACS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-09-28 | — | — | WO | disclosed |