Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 3/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 5/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 9/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.40 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | PDE8A | O60658 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CCND1 | P24385 | 3/20 | 0.36 |
| ▸ | CCND2 | P30279 | 3/20 | 0.36 |
| ▸ | CCND3 | P30281 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2612345 | 0.83 | PDE1B (0.54) | PDE1BPDE1APDE1CPDE4APDE5A | |
| SCHEMBL9608346 | 0.77 | PRKDC (0.49) | PRKDCPIK3CAMTOR | |
| SCHEMBL679839 | 0.77 | PRKDC (0.35) | PDE1BPDE1APDE1CPRKDCPIK3CA | |
| SCHEMBL194043 | 0.77 | PDE1B (0.58) | PDE1BPDE1APDE1CPRKDCPIK3CA | |
| SCHEMBL193817 | 0.76 | PDE1B (0.57) | PDE1BPDE1APDE1CPRKDCPIK3CA | |
| SCHEMBL2612348 | 0.69 | PDE1B (0.69) | PDE1BPDE1APDE1CPDE4APDE5A | |
| SCHEMBL2612350 | 0.68 | PDE1B (0.45) | PDE1BPDE1APDE1CPRKDCPDE4A | |
| SCHEMBL13334384 | 0.68 | PRKDC (0.48) | PDE1BPRKDCPIK3CAPDE4APDE5A | |
| SCHEMBL15943433 | 0.68 | PDE4A (0.39) | PDE1BPDE1APDE1CPRKDCPIK3CA | |
| SCHEMBL8059501 | 0.68 | PDE1B (0.57) | PDE1BPDE1APDE1CPRKDCPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094966-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094966-A1 | ORGANIC COMPOUNDS | TPMT, CYP4X1, P2RX4 | PDE1B 4847/4885PDE1A 4868/4885PDE1C 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.