Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11514807 | 0.89 | PTPN1 (0.46) | DAOPIM1CHEK1FLT3AURKA | |
| SCHEMBL11583004 | 0.87 | PTPN1 (0.45) | DAOPIM1CHEK1FLT3AURKA | |
| SCHEMBL11583007 | 0.87 | PTPN1 (0.45) | DAOPIM1CHEK1FLT3AURKA | |
| SCHEMBL3526289 | 0.84 | DAO (0.61) | DAOPIM1CHEK1FLT3AURKA | |
| SCHEMBL30716975 | 0.76 | DAO (0.53) | DAOAKR1C3AKR1C2PTPN1GABRP | |
| SCHEMBL481873 | 0.76 | DAO (0.72) | DAOPIM1CLK2GSK3AGSK3B | |
| SCHEMBL14644667 | 0.76 | DAO (0.53) | DAOAKR1C3AKR1C2 | |
| SCHEMBL482202 | 0.76 | DAO (0.53) | DAOAKR1C3AKR1C2PTPN1GABRP | |
| SCHEMBL31538134 | 0.76 | DAO (0.53) | DAOAKR1C3AKR1C2 | |
| SCHEMBL1431071 | 0.73 | PIM1 (0.50) | PIM1CHEK1FLT3AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| CN-103382187-B | 3-chloro-7(5)-bromo-benzo-isoxazole compounding method | SYNTHESIS MED SHANGHAI CO LTD | 2015-06-03 | — | — | CN | disclosed |
| CN-103382187-A | 3-chloro-7(5)-bromo-benzo-isoxazole compounding method | SYNTHESIS MED SHANGHAI CO LTD | 2013-11-06 | — | — | CN | disclosed |