Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.70 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.70 |
| ▸ | MTOR | P42345 | 6/20 | 0.47 |
| ▸ | RICTOR | Q6R327 | 5/20 | 0.47 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.47 |
| ▸ | MAPKAP1 | Q9BPZ7 | 5/20 | 0.47 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16727876 | 0.90 | PIK3CA (0.75) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL26113276 | 0.89 | PIK3CA (0.74) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL26578625 | 0.88 | PIK3CA (0.73) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL30598745 | 0.88 | PIK3CA (0.73) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL16611275 | 0.87 | PIK3CA (0.74) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL16611305 | 0.84 | PIK3CA (0.81) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL26135094 | 0.82 | PIK3CA (0.75) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL21929582 | 0.81 | PIK3CA (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL30805543 | 0.80 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL29183798 | 0.80 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024086664-A2 | COVALENT INHIBITORS OF WILD-TYPE AND MUTANT PI3K AND METHOD OF USES THEREOF | TOTUS MEDICINES INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| WO-2024086664-A2 | COVALENT INHIBITORS OF WILD-TYPE AND MUTANT PI3K AND METHOD OF USES THEREOF | TOTUS MEDICINES INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| WO-2023183936-A2 | COMBINATION THERAPY OF A PI3K INHIBITOR AND KRAS INHIBITOR AND METHODS OF USE THEREOF | TOTUS MEDICINES INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| WO-2023183936-A2 | COMBINATION THERAPY OF A PI3K INHIBITOR AND KRAS INHIBITOR AND METHODS OF USE THEREOF | TOTUS MEDICINES INC. (US) | 2023-09-28 | — | — | WO | disclosed |