Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.80 |
| ▸ | GAA | P10253 | 7/20 | 0.80 |
| ▸ | POLB | P06746 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.74 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | NSD2 | O96028 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | MPI | P34949 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26115021 | 1.00 | MAPT (0.80) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL31653615 | 1.00 | MAPT (0.80) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL6712598 | 0.89 | MAPT (1.00) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL11961916 | 0.80 | MAPT (0.79) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL11900618 | 0.80 | MAPT (0.79) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL1444576 | 0.80 | MAPT (0.69) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL11961917 | 0.80 | MAPT (0.69) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL17903202 | 0.79 | KMT2A (0.70) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL22892508 | 0.79 | MAPT (0.71) | MAPTGAAPOLBLMNAKDM4E | |
| SCHEMBL26135049 | 0.79 | KMT2A (0.65) | MAPTGAAPOLBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023187783-A1 | COMPOUNDS USABLE AS MODULATORS OF PERK ACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2023-10-05 | — | — | WO | disclosed |