SCHEMBL26136309

SCHEMBL26136309

COc1cc(Cn2ccc(CNC(=O)C(F)(F)F)n2)cc2onc(NS(=O)(=O)Cc3ccccc3)c12

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KAT7 O95251 20/20 0.53
KAT6A Q92794 20/20 0.53
KAT6B Q8WYB5 9/20 0.53
KAT5 Q92993 9/20 0.53
KAT8 Q9H7Z6 9/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26075899 0.90 KAT7 (0.51) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30545775 0.90 KAT7 (0.51) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30545637 0.89 KAT7 (0.52) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26136216 0.89 KAT7 (0.60) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26073886 0.89 KAT7 (0.52) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26075900 0.86 KAT7 (0.58) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26073887 0.84 KAT7 (0.53) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL30545757 0.84 KAT7 (0.53) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL31120828 0.84 KAT7 (0.53) KAT7KAT6AKAT6BKAT5KAT8
SCHEMBL26073885 0.81 KAT7 (0.42) KAT7KAT6AKAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023192817-A1 INHIBITORS OF THE MYST FAMILY OF LYSINE ACETYL TRANSFERASES Isosterix, Inc. (US) 2023-10-05 WO disclosed