Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26129610 | 0.81 | CSNK2A1 (0.44) | CSNK2A1ARAHREGFRRHEB | |
| SCHEMBL24787431 | 0.78 | CSNK2A1 (0.42) | CSNK2A1AHREGFRRHEBCCR8 | |
| SCHEMBL21243088 | 0.78 | CSNK2A1 (0.42) | CSNK2A1AHREGFRRHEBCCR8 | |
| SCHEMBL24787445 | 0.74 | CSNK2A1 (0.39) | CSNK2A1AHREGFRRHEBHSD17B10 | |
| SCHEMBL29860220 | 0.72 | AHR (0.42) | CSNK2A1ARAHREGFRRHEB | |
| SCHEMBL264807 | 0.72 | AHR (0.42) | CSNK2A1ARAHREGFRRHEB | |
| SCHEMBL31341960 | 0.70 | CSNK2A1 (0.38) | CSNK2A1AHREGFRRHEBCCR8 | |
| SCHEMBL24787449 | 0.70 | TNF (0.47) | CSNK2A1ARAHREGFRRHEB | |
| SCHEMBL31527469 | 0.70 | CSNK2A1 (0.38) | CSNK2A1ARAHREGFRCCR8 | |
| SCHEMBL4418773 | 0.70 | CCR8 (0.40) | AHRCCR8HSD17B10ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230151002-A1 | 6-5 FUSED RINGS AS C5a INHIBITORS | CHEMOCENTRYX, INC. | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230151002-A1 | 6-5 FUSED RINGS AS C5a INHIBITORS | C5AR1, C5AR2, C3AR1 | CSNK2A1 2635/4885AR 2141/4885AHR 2160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.