Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.61 |
| ▸ | FLT1 | P17948 | 3/20 | 0.61 |
| ▸ | LYN | P07948 | 3/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.61 |
| ▸ | FLT4 | P35916 | 2/20 | 0.61 |
| ▸ | PDXK | O00764 | 1/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.61 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.61 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 11/20 | 0.59 |
| ▸ | TEK | Q02763 | 11/20 | 0.59 |
| ▸ | MET | P08581 | 10/20 | 0.59 |
| ▸ | LCK | P06239 | 8/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | FGR | P09769 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069024 | 0.92 | KDR (0.51) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL2614561 | 0.91 | KDR (0.74) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL2614553 | 0.90 | KDR (0.60) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL2097763 | 0.86 | KDR (0.83) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL2614559 | 0.85 | KDR (0.64) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL2622081 | 0.84 | KDR (0.61) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL2614554 | 0.83 | KDR (0.65) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL14069008 | 0.82 | KDR (0.51) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL2614562 | 0.81 | KDR (0.63) | KDRAURKBFLT1LYNFGFR1 | |
| SCHEMBL4548961 | 0.80 | KDR (0.73) | KDRAURKBFLT1LYNFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513283-B2 | Spiro substituted compounds as angiogenesis inhibitors | ADVENCHEN LABORATORIES, LLC (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120165371-A1 | SPIRO SUBSTITUTED COMPOUNDS AS ANGIOGENESIS INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-06-28 | — | — | US | disclosed |
| US-8163923-B2 | Benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate; cancers associated with protein tyrosine kinases | ADVENCHEN LABORATORIES, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163923-B2 | Benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate; cancers associated with protein tyrosine kinases | ADVENCHEN LABORATORIES, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080227812-A1 | Spiro Substituted Compounds As Angiogenesis Inhibitors | ADVENCHEN LABORATORIES, LLC | 2008-09-18 | — | — | US | disclosed |
| US-20080227812-A1 | Spiro Substituted Compounds As Angiogenesis Inhibitors | ADVENCHEN LABORATORIES, LLC | 2008-09-18 | — | — | US | disclosed |
| WO-2008112408-A1 | SPIRO SUBSTITUTED COMPOUNDS AS ANGIOGENESIS INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165371-A1 | SPIRO SUBSTITUTED COMPOUNDS AS ANGIOGENESIS INHIBITORS | TEK, KDR, TIE1 | KDR 2/4885AURKB 247/4885FLT1 4/4885 |
| US-20080227812-A1 | Spiro Substituted Compounds As Angiogenesis Inhibitors | TEK, KDR, TIE1 | KDR 2/4885AURKB 247/4885FLT1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.