SCHEMBL26145950

SCHEMBL26145950

COc1cccc2c1ncc1c(=O)n(C3CCC(C(=O)O)CC3)c(=O)n(-c3cccc(Cl)c3)c12

nearest known ligand 0.88

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ TNF P01375 19/20 0.88
▸ LITAF Q99732 19/20 0.88
▸ PDE4B Q07343 4/20 0.88
▸ PDE4D Q08499 4/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31355049 1.00 TNF (0.88) TNFLITAFPDE4BPDE4D
SCHEMBL24164518 1.00 TNF (0.88) TNFLITAFPDE4BPDE4D
SCHEMBL29514464 1.00 TNF (0.88) TNFLITAFPDE4BPDE4D
SCHEMBL26145969 1.00 TNF (0.88) TNFLITAFPDE4BPDE4D
SCHEMBL29381799 1.00 TNF (0.88) TNFLITAFPDE4BPDE4D
Hydrochloric Acid SCHEMBL29384439 0.99 TNF (0.86) TNFLITAFPDE4BPDE4D
SCHEMBL2016365 0.93 TNF (1.00) TNFLITAFPDE4BPDE4D
SCHEMBL2016363 0.93 TNF (1.00) TNFLITAFPDE4BPDE4D
SCHEMBL2018501 0.93 TNF (1.00) TNFLITAFPDE4BPDE4D
Hydrochloric Acid SCHEMBL2016839 0.93 TNF (0.98) TNFLITAFPDE4BPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250000865-A1 COMPOUND FOR REDUCING URIC ACID LEVELS NEWSOARA BIOPHARMA CO., LTD. (CN) 2025-01-02 — — US disclosed
WO-2023083296-A1 COMPOUND FOR REDUCING URIC ACID LEVELS 恒翼生物医药(上海)股份有限公司 2023-05-19 — — WO disclosed
CN-113768937-B Compounds for reducing uric acid levels 恒翼生物医药科技(上海)有限公司 2022-04-08 — — CN disclosed
CN-113768937-A Compounds for reducing uric acid levels 恒翼生物医药科技(上海)有限公司 2021-12-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250000865-A1 COMPOUND FOR REDUCING URIC ACID LEVELS PDE4A, PDE4B, PDE12 TNF 526/4885LITAF 1814/4885PDE4B 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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