Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 4/20 | 0.74 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.74 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.74 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.74 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.74 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26168391 | 0.86 | PTPN22 (0.83) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL25248127 | 0.85 | PTPN22 (1.00) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL14444606 | 0.85 | PTPN22 (1.00) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL25248130 | 0.85 | PTPN22 (1.00) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL25244364 | 0.84 | PTPN22 (0.70) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL25244363 | 0.84 | PTPN22 (0.70) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL26168393 | 0.84 | PTPN22 (0.83) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL25218896 | 0.84 | PTPN5 (0.69) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL26168386 | 0.84 | PTPN22 (0.75) | PTPN22PTPN5PTPN1PTPN7DUSP3 | |
| SCHEMBL25267615 | 0.81 | PTPN22 (0.71) | PTPN22PTPN5PTPN1PTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091674-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-05-25 | — | — | WO | disclosed |