Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.53 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175275 | 0.91 | AXL (0.67) | KITNTRK1MAP3K11AXLCDK8 | |
| SCHEMBL26175479 | 0.89 | KIT (0.62) | KITPIK3CANTRK1DYRK1ACCNT1 | |
| SCHEMBL26175478 | 0.88 | KIT (0.67) | KITPIK3CANTRK1DYRK1ACCNT1 | |
| SCHEMBL26175549 | 0.84 | KIT (0.50) | KITPIK3CANTRK1DYRK1AMAP3K11 | |
| SCHEMBL20292991 | 0.84 | DYRK1B (0.67) | DYRK1ACDK2CDK9DYRK1B | |
| SCHEMBL26175445 | 0.83 | KIT (0.60) | KITPIK3CANTRK1DYRK1ACCNT1 | |
| SCHEMBL26175512 | 0.83 | KIT (0.50) | KITDYRK1ACDK2MAP3K11AXL | |
| SCHEMBL8941831 | 0.82 | JAK2 (0.61) | KITDYRK1ACCNT1CCNA2CDK2 | |
| SCHEMBL26174726 | 0.82 | CLK4 (0.52) | KITDYRK1ACCNT1CCNA2CDK2 | |
| SCHEMBL20319257 | 0.82 | DYRK1A (0.50) | KITDYRK1ACDK2MAP3K11AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | KIT 4356/4885PIK3CA 498/4885NTRK1 141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.