Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ATIC | P31939 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005220 | 0.84 | PARP1 (0.53) | PARP1CHEK1GRM5ROCK2ROCK1 | |
| SCHEMBL31352392 | 0.76 | CHEK1 (0.77) | PARP1CHEK1ROCK2ALDH1A1 | |
| SCHEMBL1536413 | 0.76 | PARP1 (0.53) | PARP1CHEK1MAPK14ROCK1PRKACA | |
| SCHEMBL31038353 | 0.76 | PARP1 (0.53) | PARP1CHEK1ATICGRM5ROCK2 | |
| SCHEMBL1038250 | 0.76 | PARP1 (0.53) | PARP1CHEK1ATICGRM5ROCK2 | |
| SCHEMBL1868599 | 0.76 | AHR (0.53) | PARP1CHEK1MAPK14ROCK1PRKACA | |
| SCHEMBL3004117 | 0.76 | PARP1 (0.53) | PARP1CHEK1ATICGRM5ROCK2 | |
| SCHEMBL1536457 | 0.76 | CHEK1 (0.77) | PARP1CHEK1ROCK2ALDH1A1 | |
| SCHEMBL29379996 | 0.76 | PARP1 (0.53) | PARP1CHEK1ATICGRM5ROCK2 | |
| SCHEMBL30349914 | 0.76 | PARP1 (0.53) | PARP1CHEK1ATICGRM5ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094997-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094997-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC1, HDAC5 | PARP1 383/4885CHEK1 2998/4885ATIC 4052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.