Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | SHH | Q15465 | 1/20 | 0.44 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.41 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26035454 | 0.91 | MAPK14 (0.46) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1018848 | 0.90 | ALB (0.56) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12918740 | 0.90 | ALB (0.44) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL2619411 | 0.90 | ALB (0.44) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL2619525 | 0.87 | GRM4 (0.49) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12727319 | 0.86 | MAPT (0.43) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL2619584 | 0.85 | ALB (0.44) | ALBHTR1ASLC6A2PDE4AOPRM1 | |
| SCHEMBL13628632 | 0.85 | ALB (0.46) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL1018025 | 0.84 | ALB (0.55) | GRM4ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL26038146 | 0.83 | ALB (0.56) | GRM4ALBHTR1ASLC6A2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GUNZNER JANET L (US) | 2012-04-19 | — | — | US | disclosed |
| US-8030454-B2 | Anti-hedgehog antibodies | GENENTECH, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100003239-A1 | ANTI-HEDGEHOG ANTIBODIES | GENENTECH, INC. (US) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003239-A1 | ANTI-HEDGEHOG ANTIBODIES | SHH, SMO, GLI1 | GRM4 2324/4885ALB 4485/4885HTR1A 4058/4885 |
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | GRM4 1839/4885ALB 4881/4885HTR1A 1322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.