Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262200 | 0.87 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL262201 | 0.87 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL263180 | 0.86 | MEN1 (0.50) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL263181 | 0.86 | MEN1 (0.50) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL263349 | 0.84 | MEN1 (0.46) | MEN1GAAKMT2ACNR1CNR2 | |
| SCHEMBL261584 | 0.82 | MEN1 (0.45) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL261583 | 0.82 | MEN1 (0.45) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL263848 | 0.82 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL263849 | 0.82 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1ALDH1A1 | |
| SCHEMBL262375 | 0.81 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |