Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 12/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15165552 | 0.82 | BACE1 (0.34) | BACE1BACE2 | |
| SCHEMBL2622874 | 0.81 | BACE1 (0.49) | BACE1BACE2 | |
| SCHEMBL2632346 | 0.65 | BACE1 (0.39) | BACE1BACE2TAAR1KCNH2 | |
| SCHEMBL2107228 | 0.61 | BACE1 (0.58) | BACE1BACE2 | |
| SCHEMBL1934833 | 0.61 | BACE1 (0.79) | BACE1BACE2 | |
| SCHEMBL31081766 | 0.60 | TAAR1 (0.44) | TAAR1 | |
| SCHEMBL31081818 | 0.60 | TAAR1 (0.44) | TAAR1 | |
| SCHEMBL8030939 | 0.59 | BACE1 (0.33) | BACE1BACE2TAAR1 | |
| SCHEMBL16433659 | 0.59 | BACE1 (0.68) | BACE1BACE2KCNH2 | |
| SCHEMBL2631624 | 0.59 | BACE1 (0.68) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158620-B2 | Fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-17 | — | — | US | disclosed |
| US-8158620-B2 | Fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-17 | — | — | US | disclosed |