⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194180 | 0.98 | HDAC4 (0.31) | — | |
| SCHEMBL2193482 | 0.98 | HDAC4 (0.31) | — | |
| SCHEMBL261203 | 0.93 | — | — | |
| SCHEMBL262147 | 0.80 | — | — | |
| SCHEMBL1134992 | 0.75 | KDM1A (0.36) | — | |
| SCHEMBL11783718 | 0.73 | — | — | |
| SCHEMBL8414433 | 0.72 | KDM1A (0.34) | — | |
| SCHEMBL10876875 | 0.72 | KDM1A (0.34) | — | |
| SCHEMBL10876868 | 0.72 | KDM1A (0.34) | — | |
| SCHEMBL10876862 | 0.72 | KDM1A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 278 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045108-A | Herbicidal and plant growth-regulating N-aryl-pyrrol-L-one and isoindol-2-one compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | claimed |
| US-4814271-A | Method for detecting esterolytic and proteolytic enzymes | MILES INC. (US) | 1989-03-21 | — | — | US | claimed |
| EP-3957627-B1 | 6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | SHIONOGI & CO (JP) | 2024-06-19 | — | — | EP | disclosed |
| US-11897899-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | SHIONOGI & CO., LTD. (JP) | 2024-02-13 | — | — | US | disclosed |
| EP-3495363-B1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT | SHIONOGI & CO (JP) | 2023-08-23 | — | — | EP | disclosed |
| US-11685740-B2 | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2023-06-27 | — | — | US | disclosed |
| CN-115093408-A | Benzylamine-containing 5, 6-heteroaromatic compounds useful against mycobacterial infections | 盐野义制药株式会社 | 2022-09-23 | — | — | CN | disclosed |
| EP-3412663-B1 | NITROGEN-CONTAINING HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2022-09-07 | — | — | EP | disclosed |
| US-20220235047-A1 | A MEDICAMENT FOR TREATING MYCOBACTERIAL INFECTION CHARACTERIZED BY COMBINING A CYTOCHROME bc1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN AND CLOFAZIMINE | SHIONOGI & CO., LTD. (JP) | 2022-07-28 | — | — | US | disclosed |
| EP-4028130-A1 | BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION | Shionogi & Co., Ltd (JP) | 2022-07-20 | — | — | EP | disclosed |
| WO-2022119899-A1 | A MEDICAMENT FOR TREATING MYCOBACTERIAL INFECTION CHARACTERIZED BY COMBINING A CYTOCHROME BC1 INHIBITOR WITH CLARITHROMYCIN OR AZITHROMYCIN | SHIONOGI & CO., LTD. (JP) | 2022-06-09 | — | — | WO | disclosed |
| EP-0932079-A1 | Silver halide color photographic light-sensitive material and method for forming an image using the same | FUJI PHOTO FILM CO., LTD. (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5045108-A | Herbicidal and plant growth-regulating N-aryl-pyrrol-L-one and isoindol-2-one compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0157360-B1 | CHROMOGENIC ESTERS OF AMINO ACIDS AND PEPTIDES, PROCESSES FOR THEIR PREPARATION, USE OF THESE AGENTS IN METHODS OF ANALYSIS AND AGENTS FOR DETECTION OF ESTEROLYTIC AND/OR PROTEOLYTIC ENZYMES | MILES INC. (US) | 1991-08-14 | — | — | EP | disclosed |
| EP-0403891-A1 | N-Aryl-nitrogen-heterocyclic compounds | BAYER AG (DE) | 1990-12-27 | — | — | EP | disclosed |
| US-4814271-A | Method for detecting esterolytic and proteolytic enzymes | MILES INC. (US) | 1989-03-21 | — | — | US | disclosed |
| US-4806423-A | Agents and process for the detection of esterolytic and/or proteolytic enzymes | MILES INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4723020-A | Chromogenic amino acid esters and peptide esters | MILES LABORATORIES, INC. (US) | 1988-02-02 | — | — | US | disclosed |
| EP-0157362-A2 | Chromogenic amino acids and peptide esters, process for their preparation, use of these compounds in analytical processes, as well as agents for marking esterolytic and/or proteolytic enzymes | MILES INC. (US) | 1985-10-09 | — | — | EP | disclosed |
| EP-0157360-A2 | Chromogenic esters of amino acids and peptides, processes for their preparation, use of these agents in methods of analysis and agents for detection of esterolytic and/or proteolytic enzymes | MILES INC. (US) | 1985-10-09 | — | — | EP | disclosed |