Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.63 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.63 |
| ▸ | KDM1A | O60341 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2622709 | 0.95 | HDAC6 (0.65) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2622718 | 0.91 | HDAC3 (0.50) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL16472196 | 0.88 | HDAC3 (0.48) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2622720 | 0.87 | HDAC3 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2622716 | 0.85 | HDAC3 (0.51) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL13037099 | 0.85 | HDAC1 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2622725 | 0.85 | HDAC6 (0.52) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2622714 | 0.82 | HDAC1 (0.48) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL2622711 | 0.82 | HDAC3 (0.48) | HDAC6HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL23055123 | 0.79 | HDAC6 (0.47) | HDAC6HDAC1HDAC3HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENT AB (SE) | 2017-01-26 | — | — | US | disclosed |
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB | 2014-02-20 | — | — | US | disclosed |
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | CERENO SCIENTIFIC AB | 2014-02-20 | — | — | US | disclosed |
| US-8163765-B2 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-24 | — | — | US | disclosed |
| US-8163765-B2 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-24 | — | — | US | disclosed |
| US-20110118291-A1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-19 | — | — | US | disclosed |
| US-20110118291-A1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-05-19 | — | — | US | disclosed |
| US-7834025-B2 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-16 | — | — | US | disclosed |
| US-7834025-B2 | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-11-16 | — | — | US | disclosed |
| US-20090018153-A1 | Substituted Indolyl-Alkyl-Amino-Derivatives as Inhibitors of Histone Deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-15 | — | — | US | disclosed |
| US-20090018153-A1 | Substituted Indolyl-Alkyl-Amino-Derivatives as Inhibitors of Histone Deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051716-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC6 10/4885HDAC1 2/4885HDAC3 1/4885 |
| US-20170020874-A1 | COMPOUNDS AND METHODS FOR IMPROVING IMPAIRED ENDOGENOUS FIBRINOLYSIS USING HISTONE DEACETYLASE INHIBITORS | HDAC3, HDAC1, HDAC2 | HDAC6 10/4885HDAC1 2/4885HDAC3 1/4885 |
| US-20090018153-A1 | Substituted Indolyl-Alkyl-Amino-Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC3, HDAC2 | HDAC6 12/4885HDAC1 1/4885HDAC3 2/4885 |
| US-20110118291-A1 | SUBSTITUTED INDOLYL-ALKYL-AMINO-DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | HDAC6 12/4885HDAC1 1/4885HDAC3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.