Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | UBE2M | P61081 | 1/20 | 0.30 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262831 | 0.86 | MEN1 (0.47) | KMT2AMEN1GAAFOXO1PDE10A | |
| SCHEMBL4180734 | 0.84 | MEN1 (0.49) | KMT2AMEN1GAAFOXO1CREBBP | |
| Hydrochloric Acid SCHEMBL261650 | 0.84 | MEN1 (0.52) | KMT2AMEN1GAAFOXO1CREBBP | |
| SCHEMBL265623 | 0.83 | KMT2A (0.53) | KMT2AMEN1GAAFOXO1CREBBP | |
| SCHEMBL263296 | 0.83 | MEN1 (0.45) | KMT2AMEN1GAAFOXO1CREBBP | |
| SCHEMBL4165411 | 0.80 | MEN1 (0.52) | KMT2AMEN1GAAFOXO1CREBBP | |
| SCHEMBL261932 | 0.80 | MEN1 (0.52) | KMT2AMEN1GAAFOXO1CREBBP | |
| SCHEMBL261474 | 0.79 | KMT2A (0.49) | KMT2AMEN1GAAFOXO1CREBBP | |
| SCHEMBL262164 | 0.79 | MEN1 (0.52) | KMT2AMEN1GAAFOXO1CREBBP | |
| SCHEMBL261593 | 0.79 | KMT2A (0.49) | KMT2AMEN1GAAFOXO1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |