Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.78 |
| ▸ | LCK | P06239 | 10/20 | 0.78 |
| ▸ | EGFR | P00533 | 8/20 | 0.78 |
| ▸ | ITK | Q08881 | 8/20 | 0.78 |
| ▸ | JAK3 | P52333 | 4/20 | 0.78 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.59 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 4/20 | 0.53 |
| ▸ | LYN | P07948 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 4/20 | 0.53 |
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.53 |
| ▸ | HCK | P08631 | 3/20 | 0.53 |
| ▸ | FGR | P09769 | 3/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.53 |
| ▸ | YES1 | P07947 | 2/20 | 0.53 |
| ▸ | BLK | P51451 | 2/20 | 0.53 |
| ▸ | BMX | P51813 | 2/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14617775 | 0.91 | BTK (0.80) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14617768 | 0.91 | BTK (0.80) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL17090645 | 0.91 | BTK (0.80) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL14643775 | 0.89 | BTK (0.78) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL410081 | 0.89 | BTK (0.82) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL22300431 | 0.88 | BTK (0.71) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL18476811 | 0.88 | BTK (0.78) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL409516 | 0.88 | BTK (0.75) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL409254 | 0.88 | BTK (1.00) | BTKLCKEGFRITKJAK3 | |
| SCHEMBL29663809 | 0.88 | BTK (1.00) | BTKLCKEGFRITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293532-A1 | USE OF INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) | PHARMACYCLICS LLC (US) | 2023-09-21 | — | — | US | disclosed |
| US-9862722-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2018-01-09 | — | — | US | disclosed |
| US-20150329550-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC (US) | 2015-11-19 | — | — | US | disclosed |
| US-9138436-B2 | Inhibitors of Bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2015-09-22 | — | — | US | disclosed |
| US-20130018032-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2013-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329550-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885LCK 19/4885EGFR 947/4885 |
| US-20130018032-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885LCK 19/4885EGFR 947/4885 |
| US-20230293532-A1 | USE OF INHIBITORS OF BRUTONS TYROSINE KINASE (BTK) | BTK, LYN, SYK | BTK 1/4885LCK 5/4885EGFR 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.