Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | TOP2A | P11388 | 2/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169523 | 0.91 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL4169519 | 0.91 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL263349 | 0.87 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL4180729 | 0.86 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL4180728 | 0.86 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL262447 | 0.86 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL262243 | 0.84 | MEN1 (0.49) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL263535 | 0.83 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL263832 | 0.82 | MEN1 (0.51) | MEN1GAAKMT2AFOXO1KDM4E | |
| SCHEMBL4172238 | 0.81 | MEN1 (0.51) | MEN1GAAKMT2AFOXO1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |