Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 14/20 | 1.00 |
| ▸ | CSNK2B | P67870 | 13/20 | 1.00 |
| ▸ | CSNK2A2 | P19784 | 12/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 12/20 | 1.00 |
| ▸ | CSNK2A3 | Q8NEV1 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL261139 | 0.78 | CSNK2B (1.00) | CSNK2A1CSNK2BCSNK2A2ABCG2CSNK2A3 | |
| SCHEMBL263079 | 0.73 | ABCG2 (1.00) | CSNK2A1CSNK2BCSNK2A2ABCG2CSNK2A3 | |
| SCHEMBL7689177 | 0.70 | CSNK2A2 (0.54) | CSNK2A1CSNK2BCSNK2A2ABCG2HPGD | |
| SCHEMBL20944795 | 0.67 | TDP1 (0.65) | CSNK2A1CSNK2BCSNK2A2CSNK2A3TDP1 | |
| SCHEMBL6689292 | 0.67 | CSNK2A2 (0.50) | CSNK2A1CSNK2BCSNK2A2ABCG2NPSR1 | |
| SCHEMBL263321 | 0.67 | CSNK2B (0.80) | CSNK2A1CSNK2BCSNK2A2ABCG2CSNK2A3 | |
| SCHEMBL261530 | 0.66 | CSNK2B (1.00) | CSNK2A1CSNK2BCSNK2A2ABCG2CSNK2A3 | |
| SCHEMBL30631777 | 0.62 | CSNK2A2 (0.52) | CSNK2A1CSNK2BCSNK2A2ABCG2CSNK2A3 | |
| SCHEMBL20944806 | 0.62 | CSNK2A2 (0.52) | CSNK2A1CSNK2BCSNK2A2ABCG2CSNK2A3 | |
| SCHEMBL22541425 | 0.62 | NTRK1 (0.79) | CSNK2A1CSNK2BCSNK2A2ABCG2CSNK2A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133913-B2 | Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids | Heinrich-Heine Universitat Dusseldof (DE) | 2012-03-13 | — | — | US | disclosed |
| US-20100056599-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | HEINRICH-HEINE UNIVERSITAT DUSSELDORF (DE) | 2010-03-04 | — | — | US | disclosed |
| EP-2079691-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | Heinrich-Heine-Universität Düsseldorf (DE) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008040547-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF (DE) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056599-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | CDK2, CSNK1A1, CDK1 | CSNK2A1 4/4885CSNK2B 11/4885CSNK2A2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.