SCHEMBL2628126

SCHEMBL2628126

N#Cc1c(Cl)cccc1Oc1cccc(Oc2cccc(Oc3ccc4ccc(Oc5cccc(Cl)c5C#N)cc4c3)c2C#N)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 1/20 0.49
MAPT P10636 2/20 0.48
HSD11B1 P28845 1/20 0.45
CASR P41180 7/20 0.44
GAA P10253 1/20 0.43
RCE1 Q9Y256 1/20 0.43
AR P10275 2/20 0.42
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
BCL2L1 Q07817 1/20 0.41
MCL1 Q07820 1/20 0.41
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
ADRB2 P07550 2/20 0.39
CYP2D6 P10635 2/20 0.39
SLC6A2 P23975 2/20 0.39
SLC6A4 P31645 2/20 0.39
SLC6A3 Q01959 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2628137 0.96 TLR8 (0.52) TLR8MAPTHSD11B1CASRGAA
SCHEMBL12960259 0.93 TLR8 (0.54) TLR8MAPTHSD11B1CASRGAA
SCHEMBL2628138 0.92 TLR8 (0.47) TLR8MAPTHSD11B1CASRGAA
SCHEMBL2628123 0.92 TLR8 (0.56) TLR8MAPTHSD11B1CASRGAA
SCHEMBL2628131 0.91 MAPT (0.51) TLR8MAPTHSD11B1CASRGAA
SCHEMBL3138718 0.89 TLR8 (0.53) TLR8MAPTHSD11B1CASRAR
SCHEMBL2628132 0.88 TLR8 (0.45) TLR8MAPTHSD11B1CASRGAA
SCHEMBL2628133 0.88 TLR8 (0.45) TLR8MAPTHSD11B1CASRGAA
SCHEMBL2628127 0.84 TLR8 (0.44) TLR8MAPTHSD11B1CASRGAA
SCHEMBL2628130 0.83 TLR8 (0.43) TLR8MAPTHSD11B1CASRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8163406-B2 Membrane-electrode assembly for solid polymer electrolyte fuel cell HONDA MOTOR CO., LTD. (JP) 2012-04-24 US disclosed
US-20080160381-A1 MEMBRANE-ELECTRODE ASSEMBLY FOR SOLID POLYMER ELECTROLYTE FUEL CELL HONDA MOTOR CO., LTD. (JP) 2008-07-03 US disclosed