Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.83 |
| ▸ | CDK6 | Q00534 | 14/20 | 0.83 |
| ▸ | CCND3 | P30281 | 14/20 | 0.83 |
| ▸ | CDK1 | P06493 | 14/20 | 0.83 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.83 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.83 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.83 |
| ▸ | CDK2 | P24941 | 3/20 | 0.83 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.83 |
| ▸ | CDK9 | P50750 | 3/20 | 0.83 |
| ▸ | CCND1 | P24385 | 2/20 | 0.83 |
| ▸ | CDK7 | P50613 | 2/20 | 0.83 |
| ▸ | CCNH | P51946 | 2/20 | 0.83 |
| ▸ | CIT | O14578 | 1/20 | 0.83 |
| ▸ | GAK | O14976 | 1/20 | 0.83 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.83 |
| ▸ | STK16 | O75716 | 1/20 | 0.83 |
| ▸ | CCNK | O75909 | 1/20 | 0.83 |
| ▸ | STK10 | O94804 | 1/20 | 0.83 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17488700 | 0.92 | CDK4 (0.82) | CDK4CDK6CCND3CDK1CCNE1 | |
| Abemaciclib SCHEMBL29591527 | 0.91 | CDK4 (1.00) | CDK4CDK6CCND3CDK1CCNE1 | |
| Abemaciclib SCHEMBL2487229 | 0.91 | CDK4 (1.00) | CDK4CDK6CCND3CDK1CCNE1 | |
| Abemaciclib SCHEMBL29356350 | 0.91 | CDK4 (1.00) | CDK4CDK6CCND3CDK1CCNE1 | |
| Abemaciclib SCHEMBL29423472 | 0.91 | CDK4 (1.00) | CDK4CDK6CCND3CDK1CCNE1 | |
| SCHEMBL17488760 | 0.91 | CDK4 (0.88) | CDK4CDK6CCND3CDK1CCNE1 | |
| SCHEMBL31073114 | 0.91 | CDK4 (0.75) | CDK4CDK6CCND3CDK1CCNE1 | |
| SCHEMBL17488823 | 0.90 | CDK4 (0.80) | CDK4CDK6CCND3CDK1CCNE1 | |
| SCHEMBL17488714 | 0.90 | CDK4 (0.80) | CDK4CDK6CCND3CDK1CCNE1 | |
| SCHEMBL22004900 | 0.90 | CDK4 (0.82) | CDK4CDK6CCND3CDK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295118-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF CYCLIN DEPENDENT KINASES | ENDOTARGET INC. | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295118-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF CYCLIN DEPENDENT KINASES | CDK6, CDK4, CDK1 | CDK4 2/4885CDK6 1/4885CCND3 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.