⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202105 | 0.74 | — | — | |
| SCHEMBL1825412 | 0.69 | — | — | |
| SCHEMBL21220797 | 0.69 | — | — | |
| SCHEMBL697445 | 0.68 | — | — | |
| Formic Acid SCHEMBL10713055 | 0.64 | HSD17B10 (0.42) | — | |
| SCHEMBL15929800 | 0.64 | — | — | |
| SCHEMBL12080744 | 0.64 | HSD17B10 (0.42) | — | |
| SCHEMBL22997 | 0.64 | HSD17B10 (0.47) | — | |
| SCHEMBL18277428 | 0.64 | — | — | |
| SCHEMBL7535878 | 0.64 | HSD17B10 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369498-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-12-28 | — | — | US | disclosed |
| US-9732083-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-08-15 | — | — | US | disclosed |
| US-9334273-B1 | Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150246934-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME LLC | 2015-09-03 | — | — | US | disclosed |
| US-8524943-B2 | Production of trans-4-aminocyclopent-2-ene-1-carboxylic acid derivatives | DR. REDDY'S LABORATORIES, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120238751-A1 | TRICYCLIC GYRASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120101297-A1 | PRODUCTION OF TRANS-4-AMINOCYCLOPENT-2-ENE-1-CARBOXYLIC ACID DERIVATIVES | DR. REDDY'S LABORATORIES, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-7417153-B2 | Method for the production of 3-amino-5-(hydroxymethyl)cyclopentane-1,2-diol derivatives | LONZA AG (CH) | 2008-08-26 | — | — | US | disclosed |
| US-20070043225-A1 | Method for the production of 3-amino-5-(hydroxymethyl) cyclopentane-1,2-diol-derivatives | LONZA AG (CH) | 2007-02-22 | — | — | US | disclosed |