Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8838391 | 1.00 | KLK5 (0.60) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL6861203 | 1.00 | KLK5 (0.60) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7810113 | 1.00 | KLK5 (0.60) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL3471057 | 1.00 | KLK5 (0.60) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7111203 | 1.00 | KLK5 (0.60) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7815696 | 1.00 | KLK5 (0.60) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7806327 | 0.88 | ATM (0.54) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7392856 | 0.85 | KLK5 (0.67) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7112348 | 0.84 | CPA1 (0.47) | KLK5CTSLCTSB | |
| SCHEMBL8539590 | 0.84 | KLK5 (0.66) | KLK5ATMPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118530145-A | Synthesis method of darunavir key intermediate | 江苏八巨药业有限公司 | 2024-08-23 | — | — | CN | disclosed |
| WO-2010143150-A3 | PROCESS FOR STEREOSELECTIVE PREPARATION OF AN INTERMEDIATE OF PROTEASE INHIBITORS | PIRAMAL HEALTHCARE LIMITED (IN) | 2011-03-31 | — | — | WO | disclosed |
| WO-2010143150-A2 | PROCESS FOR STEREOSELECTIVE PREPARATION OF AN INTERMEDIATE OF PROTEASE INHIBITORS | PIRAMAL HEALTHCARE LIMITED (IN) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010143150-A2 | PROCESS FOR STEREOSELECTIVE PREPARATION OF AN INTERMEDIATE OF PROTEASE INHIBITORS | PIRAMAL HEALTHCARE LIMITED (IN) | 2010-12-16 | — | — | WO | disclosed |