Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2630893 | 0.87 | PDE10A (1.00) | PDE10A | |
| SCHEMBL2631032 | 0.87 | PDE10A (0.74) | PDE10A | |
| SCHEMBL2630867 | 0.86 | PDE10A (0.69) | PDE10A | |
| SCHEMBL7705779 | 0.86 | PDE10A (0.69) | PDE10A | |
| SCHEMBL15134970 | 0.86 | PDE10A (0.84) | PDE10A | |
| SCHEMBL2630828 | 0.86 | PDE10A (1.00) | PDE10A | |
| Hydrochloric Acid SCHEMBL2630814 | 0.85 | PDE10A (0.68) | PDE10A | |
| SCHEMBL2631011 | 0.84 | — | — | |
| SCHEMBL2631155 | 0.84 | — | — | |
| SCHEMBL2631013 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569302-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | Amgen, Inc (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143495-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |