Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 7/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LPAR6 | P43657 | 3/20 | 0.32 |
| ▸ | LPAR4 | Q99677 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14755325 | 1.00 | PLA2G2C (0.35) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL2632262 | 0.88 | PLA2G2C (0.36) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL17794227 | 0.88 | PLA2G2C (0.36) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL17794223 | 0.85 | PLA2G2C (0.37) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL8020967 | 0.85 | PLA2G2C (0.37) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL10816729 | 0.85 | LPAR1 (0.46) | PLA2G2CLPAR1LPAR3LPAR2USP2 | |
| SCHEMBL11302968 | 0.84 | LPAR1 (0.49) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL13419618 | 0.83 | PRKD3 (0.46) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL12386622 | 0.83 | TSHR (0.38) | PLA2G2CTSHRLPAR1LPAR3LPAR2 | |
| SCHEMBL7916613 | 0.81 | PLA2G2C (0.33) | PLA2G2CLPAR1LPAR3LPAR2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094984-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094984-A1 | FUSED AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, APP, BACE2 | PLA2G2C 1803/4885TSHR 3087/4885LPAR1 2634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.