⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907841 | 0.56 | — | — | |
| SCHEMBL137937 | 0.56 | — | — | |
| SCHEMBL1137160 | 0.56 | — | — | |
| SCHEMBL207093 | 0.56 | — | — | |
| SCHEMBL3960783 | 0.56 | — | — | |
| SCHEMBL1554792 | 0.54 | — | — | |
| Hydrochloric Acid SCHEMBL4395993 | 0.53 | — | — | |
| Hno SCHEMBL8576318 | 0.50 | — | — | |
| Hydrochloric Acid SCHEMBL1002907 | 0.50 | — | — | |
| SCHEMBL8756 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0304910-A1 | Biarylalkylimidazole derivatives as antidepressants | G.D. Searle & Co. (US) | 1989-03-01 | — | — | EP | claimed |
| US-20170158686-A1 | Compounds Useful as Raf Kinase Inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-06-08 | — | — | US | disclosed |
| US-9556177-B2 | Substituted 1,3-thiazoles as synthetic intermediates for preparation of Raf kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20150080568-A1 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | XOMA (US) LLC | 2015-03-19 | — | — | US | disclosed |
| US-8802657-B2 | Compounds useful as Raf kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-12 | — | — | US | disclosed |
| EP-2650286-A1 | Quinazoline derivatives and therapeutic use thereof | Rexahn Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| US-8404698-B2 | Quinazoline derivatives and therapeutic use thereof | REXAHN PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20130065858-A1 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2013-03-14 | — | — | US | disclosed |
| US-8293752-B2 | Compounds useful as Raf kinase inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20120101032-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| WO-2011035159-A1 | ARYL SULPHONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | ZALICUS PHARMACEUTICALS LTD. (CA) | 2011-03-24 | — | — | WO | disclosed |
| US-20090069334-A1 | Pyridazine based alpha-helix mimetics | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20090036419-A1 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2009-02-05 | — | — | US | disclosed |
| US-20090030021-A1 | Quinazoline Derivatives and Therapeutic Use Thereof | REXAHN PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | US | disclosed |
| US-7388014-B2 | Quinazoline derivatives and therapeutic use thereof | REXAHN PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-6277957-B1 | SIMPLE, EFFICIENT, NON-NOXIOUS METHOD FOR PRODUCTION OF COMPLEX CONJUGATES LINKED TOGETHER BY AMIDE BONDS; REACTING CARBOXYLATE OR CARBOXYLIC ACID WITH ISOTHIOURONIUM DERIVATIVE IN PRESENCE OF BASE OR NEUTRALIZER | HUDSON DEREK (US) | 2001-08-21 | — | — | US | disclosed |