Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26325659 | 0.98 | HDAC8 (0.59) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26325672 | 0.97 | HDAC8 (0.58) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26325663 | 0.97 | HDAC8 (0.58) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26325689 | 0.91 | HDAC8 (0.56) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26325678 | 0.91 | HDAC8 (0.56) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26325703 | 0.91 | HDAC8 (0.56) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26325692 | 0.91 | HDAC8 (0.56) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL26325711 | 0.91 | HDAC8 (0.56) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL30883150 | 0.86 | HDAC8 (0.53) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL30883158 | 0.85 | HDAC8 (0.52) | HDAC8HDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023151113-A1 | SELECTIVE HISTONE DEACETYLASE 8 DEGRADER, PREPARATION METHOD AND APPLICATION THEREOF IN ANTI-TUMOR ACTIVITY | 深圳大学 | 2023-08-17 | — | — | WO | disclosed |