Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 13/20 | 0.55 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.55 |
| ▸ | PSMB10 | P40306 | 3/20 | 0.55 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.55 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.51 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.51 |
| ▸ | CTRL | P40313 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.51 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.51 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.51 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.51 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.51 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.51 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.51 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.51 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14208802 | 0.93 | PSMB5 (0.54) | PSMB5PSMB8PSMB10PSMB2PSMB9 | |
| SCHEMBL2632732 | 0.90 | PSMB5 (0.51) | PSMB5PSMB8PSMB10PSMB2PSMB9 | |
| SCHEMBL14208823 | 0.89 | PSMB5 (0.68) | PSMB5PSMB8PSMB10PSMB2PSMB9 | |
| SCHEMBL2632730 | 0.86 | PSMB5 (0.58) | PSMB5PSMB8PSMB10PSMB2PSMB9 | |
| SCHEMBL85018 | 0.83 | PSMB5 (0.71) | PSMB5PSMB8PSMB10PSMB2PSMB9 | |
| SCHEMBL2759972 | 0.81 | TMPRSS11D (0.56) | PSMB5PSMB8PSMB10PSMB2PSMB9 | |
| SCHEMBL85133 | 0.80 | PSMB5 (0.68) | PSMB5PSMB8PSMB10PSMB2PSMB9 | |
| SCHEMBL17948648 | 0.80 | CPA1 (0.63) | PSMB5PSMB2TMPRSS11DCTRLPSMB1 | |
| SCHEMBL2632695 | 0.80 | CPA1 (0.62) | CPA1CPA2CPA4ALDH1A1 | |
| SCHEMBL8267223 | 0.78 | PSMB5 (0.60) | PSMB5PSMB8PSMB10PSMB2PSMB9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101026-A1 | Compounds For Enzyme Inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-20120101025-A1 | Compounds For Enzyme Inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-04-26 | — | — | US | disclosed |
| US-8088741-B2 | Compounds for enzyme inhibition | ONYX THERAPEUTICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20080090785-A1 | Peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases, e.g., the chymotrypsin-like activity of the 20S proteasome; antiproliferative and antiinflammatory agents | PROTEOLIX, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| US-20080090785-A1 | Peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases, e.g., the chymotrypsin-like activity of the 20S proteasome; antiproliferative and antiinflammatory agents | PROTEOLIX, INC. (US) | 2008-04-17 | — | — | US | disclosed |
| WO-2005111008-A2 | COMPOUNDS FOR ENZYME INHIBITION | PROTEOLIX, INC. (US) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090785-A1 | Peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases, e.g., the chymotrypsin-like activity of the 20S proteasome; antiproliferative and antiinflammatory agents | ANPEP, DNPEP, CPN1 | PSMB5 25/4885PSMB8 36/4885PSMB10 20/4885 |
| US-20120101026-A1 | Compounds For Enzyme Inhibition | ANPEP, DNPEP, CPN1 | PSMB5 29/4885PSMB8 53/4885PSMB10 22/4885 |
| US-20120101025-A1 | Compounds For Enzyme Inhibition | ANPEP, DNPEP, CPN1 | PSMB5 29/4885PSMB8 53/4885PSMB10 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.