Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268236 | 0.81 | KMT2A (0.57) | KMT2ASMN1; SMN2POLBHSP90AA1HSP90AB1 | |
| SCHEMBL49946 | 0.81 | KMT2A (0.57) | KMT2ASMN1; SMN2POLBHSP90AA1HSP90AB1 | |
| SCHEMBL15196077 | 0.81 | KMT2A (0.57) | KMT2ASMN1; SMN2POLBHSP90AA1HSP90AB1 | |
| SCHEMBL2625561 | 0.81 | KMT2A (0.57) | KMT2APOLBHSP90AA1HSP90AB1NTRK1 | |
| SCHEMBL13235065 | 0.80 | KMT2A (0.73) | KMT2ASMN1; SMN2POLBRAB9ANPC1 | |
| SCHEMBL9523223 | 0.79 | KMT2A (0.55) | KMT2ASMN1; SMN2POLBHSP90AA1HSP90AB1 | |
| SCHEMBL18410063 | 0.78 | KMT2A (0.46) | KMT2ASMN1; SMN2POLBHSP90AA1HSP90AB1 | |
| SCHEMBL29128621 | 0.77 | KMT2A (0.57) | KMT2ASMN1; SMN2POLBHSP90AA1HSP90AB1 | |
| SCHEMBL13234478 | 0.77 | KMT2A (1.00) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL12035264 | 0.76 | KMT2A (0.53) | KMT2APOLBHSP90AA1HSP90AB1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |