Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 10/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189399 | 0.86 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL13452363 | 0.78 | PIK3CG (0.62) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189045 | 0.78 | PIK3CG (0.72) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189140 | 0.77 | PIK3CG (0.71) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189691 | 0.76 | PIK3CG (0.74) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL188828 | 0.75 | PIK3CG (0.78) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189686 | 0.74 | PIK3CG (0.61) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189522 | 0.72 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL189296 | 0.71 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC | |
| SCHEMBL14873744 | 0.71 | PIK3CG (0.80) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-B9 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2056829-B1 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-01-04 | — | — | EP | disclosed |