SCHEMBL26329805

SCHEMBL26329805

COc1nc(-c2cccc(-c3cccc(-c4cnc(CNCC5CCC(=O)N5)c(OC)n4)c3Cl)c2F)cnc1CNCC1CCC(=O)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 20/20 1.00
CD274 Q9NZQ7 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21289965 1.00 PDCD1 (1.00) PDCD1CD274
Evixapodlin SCHEMBL21290636 0.96 PDCD1 (1.00) PDCD1CD274
Evixapodlin SCHEMBL21274280 0.96 PDCD1 (1.00) PDCD1CD274
Evixapodlin SCHEMBL26331593 0.96 PDCD1 (1.00) PDCD1CD274
Evixapodlin SCHEMBL21290535 0.96 PDCD1 (1.00) PDCD1CD274
Evixapodlin SCHEMBL29387636 0.96 PDCD1 (1.00) PDCD1CD274
SCHEMBL21290873 0.94 CD274 (1.00) PDCD1CD274
SCHEMBL26337671 0.94 CD274 (1.00) PDCD1CD274
SCHEMBL21291111 0.94 CD274 (1.00) PDCD1CD274
SCHEMBL21274719 0.93 CD274 (1.00) PDCD1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4227302-A1 PD-1/PD-L1 INHIBITORS Gilead Sciences, Inc. (US) 2023-08-16 EP disclosed