Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL507067 | 0.93 | GSK3B (0.64) | SMN1; SMN2L3MBTL1MAPTGSK3BKMT2A | |
| Hydrochloric Acid SCHEMBL30478406 | 0.91 | GSK3B (0.61) | SMN1; SMN2L3MBTL1MAPTGSK3BKMT2A | |
| SCHEMBL10389933 | 0.91 | SMN1; SMN2 (0.83) | SMN1; SMN2L3MBTL1MAPTGSK3BKMT2A | |
| SCHEMBL16152387 | 0.88 | MAPT (0.56) | SMN1; SMN2L3MBTL1MAPTGSK3BKMT2A | |
| SCHEMBL11135945 | 0.84 | KMT2A (0.56) | SMN1; SMN2L3MBTL1MAPTGSK3BKMT2A | |
| SCHEMBL8051337 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2L3MBTL1MAPTGSK3BKMT2A | |
| SCHEMBL1928026 | 0.83 | MAPT (1.00) | SMN1; SMN2L3MBTL1MAPTGSK3BNPC1 | |
| SCHEMBL15085369 | 0.83 | SMN1; SMN2 (0.77) | SMN1; SMN2L3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL13267783 | 0.83 | MAPT (1.00) | SMN1; SMN2L3MBTL1MAPTGSK3BNPC1 | |
| SCHEMBL28427073 | 0.83 | MAPT (0.70) | SMN1; SMN2L3MBTL1MAPTGSK3BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9236571-B2 | Polymer materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2016-01-12 | — | — | US | disclosed |
| US-8921555-B2 | Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones | MERCK SHARP & DOHME CORP. (US) | 2014-12-30 | — | — | US | disclosed |
| US-8786181-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-20130207095-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | Fraunhofer-Gesellschaft Forderung E.V. (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130187096-A1 | POLYMER MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2013-07-25 | — | — | US | disclosed |
| US-20120095001-A1 | SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | MERCK SHARP & DOHME CORP. (US) | 2012-04-19 | — | — | US | disclosed |
| WO-2010147776-A1 | SUBSTITUTED -1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | MERCK SHARP & DOHME CORP. (US) | 2010-12-23 | — | — | WO | disclosed |
| US-6194599-B1 | Process for preparing biaryl compounds | CATALYTICA, INC. | 2001-02-27 | — | — | US | disclosed |
| US-5922898-A | Process for preparing biaryl compounds | CATALYTICA PHARMACEUTICALS, INC. (US) | 1999-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095001-A1 | SUBSTITUTED-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONES | HIF1AN, HIF1A, EGLN2 | SMN1; SMN2 4257/4885L3MBTL1 1811/4885MAPT 4584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.