Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 2/20 | 0.30 |
| ▸ | BIRC3 | Q13489 | 2/20 | 0.30 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13962141 | 0.91 | ADRB3 (0.39) | ADRB3ADRA2BADRA2CXIAPBIRC3 | |
| SCHEMBL13961555 | 0.88 | ADRB3 (0.39) | ADRB3ADRA2BADRA2CXIAPBIRC3 | |
| SCHEMBL2633242 | 0.86 | ADRB3 (0.38) | ADRB3ADRA2BADRA2CXIAPBIRC3 | |
| SCHEMBL13961706 | 0.86 | ADRB3 (0.35) | ADRB3ADRA2BADRA2C | |
| SCHEMBL13961563 | 0.86 | ADRB3 (0.38) | ADRB3ADRA2BADRA2C | |
| SCHEMBL14301823 | 0.86 | ADRB3 (0.36) | ADRB3ADRA2BADRA2C | |
| SCHEMBL13961550 | 0.86 | ADRB3 (0.36) | ADRB3ADRA2BADRA2C | |
| SCHEMBL2633212 | 0.86 | ADRB3 (0.36) | ADRB3ADRA2BADRA2C | |
| SCHEMBL13961549 | 0.86 | ADRB3 (0.36) | ADRB3ADRA2BADRA2C | |
| SCHEMBL2633290 | 0.86 | ADRB3 (0.37) | ADRB3ADRA2BADRA2CXIAPBIRC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043658-B1 | ANTIVIRAL PHOSPHINATE COMPOUNDS | GILEAD SCIENCES INC (US) | 2012-04-25 | — | — | EP | disclosed |
| WO-2008005565-A9 | ANTIVIRAL PHOSPHINATE COMPOUNDS | GILEAD SCIENCES INC (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2008005565-A2 | ANTIVIRAL PHOSPHINATE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2008-01-10 | — | — | WO | disclosed |