SCHEMBL26334482

SCHEMBL26334482

COc1nc(-c2cccc(-c3cccc(-c4cnc(CN[C@H]5CCC(O)C5)c(OC)n4)c3Cl)c2Cl)cnc1CNC[C@@H]1CCC(=O)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 20/20 1.00
CD274 Q9NZQ7 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21290931 1.00 PDCD1 (1.00) PDCD1CD274
SCHEMBL21290944 1.00 PDCD1 (1.00) PDCD1CD274
SCHEMBL21290949 1.00 PDCD1 (1.00) PDCD1CD274
SCHEMBL21290929 1.00 PDCD1 (1.00) PDCD1CD274
SCHEMBL21289998 0.95 PDCD1 (1.00) PDCD1CD274
SCHEMBL21289993 0.95 PDCD1 (1.00) PDCD1CD274
SCHEMBL26335866 0.95 PDCD1 (1.00) PDCD1CD274
SCHEMBL26334332 0.95 PDCD1 (1.00) PDCD1CD274
SCHEMBL21291056 0.93 PDCD1 (1.00) PDCD1CD274
SCHEMBL26333429 0.93 PDCD1 (1.00) PDCD1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4227302-A1 PD-1/PD-L1 INHIBITORS Gilead Sciences, Inc. (US) 2023-08-16 EP disclosed