Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 19/20 | 0.77 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2633951 | 0.93 | PDE10A (0.77) | PDE10A | |
| SCHEMBL2634619 | 0.89 | PDE10A (0.72) | PDE10A | |
| SCHEMBL18093488 | 0.89 | PDE10A (0.72) | PDE10A | |
| SCHEMBL7703011 | 0.87 | PDE10A (1.00) | PDE10AROCK2 | |
| SCHEMBL2634197 | 0.87 | PDE10A (1.00) | PDE10AROCK2 | |
| SCHEMBL2634200 | 0.87 | PDE10A (1.00) | PDE10AROCK2 | |
| SCHEMBL7698581 | 0.83 | PDE10A (1.00) | PDE10AROCK2 | |
| SCHEMBL9985164 | 0.83 | PDE10A (1.00) | PDE10AROCK2 | |
| SCHEMBL9985166 | 0.83 | PDE10A (1.00) | PDE10AROCK2 | |
| SCHEMBL7697496 | 0.80 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569306-A1 | HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS | Amgen Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143366-A1 | HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |