Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 18/20 | 0.71 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867411 | 0.87 | RYR2 (0.57) | RYR2 | |
| SCHEMBL13392662 | 0.83 | RYR2 (0.54) | RYR2 | |
| SCHEMBL6866692 | 0.83 | RYR2 (1.00) | RYR2 | |
| SCHEMBL7559963 | 0.80 | RYR2 (0.63) | RYR2ESR1ESR2 | |
| SCHEMBL17946170 | 0.76 | RYR2 (0.65) | RYR2 | |
| SCHEMBL22543772 | 0.75 | ESR1 (0.60) | RYR2ESR1ESR2TSHRCYP2C19 | |
| SCHEMBL13102503 | 0.75 | ESR2 (0.69) | RYR2ESR1ESR2TSHRCYP2C19 | |
| SCHEMBL6866695 | 0.74 | RYR2 (1.00) | RYR2 | |
| SCHEMBL20436334 | 0.74 | ESR1 (0.50) | RYR2ESR1ESR2TSHRCYP2C19 | |
| SCHEMBL26344276 | 0.73 | RYR2 (0.53) | RYR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230302013-A1 | METHOD OF TREATING VIRAL-INDUCED COGNITIVE DYSFUNCTION BY TARGETING LEAKY RyR2 CHANNELS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230302013-A1 | METHOD OF TREATING VIRAL-INDUCED COGNITIVE DYSFUNCTION BY TARGETING LEAKY RyR2 CHANNELS | RYR2, RYR1, CACNB1 | RYR2 1/4885ESR1 3166/4885ESR2 2370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.