Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM4 | Q8TD43 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2635601 | 0.83 | POLB (0.42) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL2636125 | 0.73 | POLB (0.44) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL2636308 | 0.73 | POLB (0.45) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL2636150 | 0.71 | SMN1; SMN2 (0.41) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL2636709 | 0.70 | POLB (0.48) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL2635666 | 0.67 | POLB (0.43) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL2635609 | 0.65 | MEN1 (0.36) | SMN1; SMN2POLBMAPTRAB9ANPC1 | |
| SCHEMBL4675125 | 0.65 | POLB (0.52) | TRPM4SMN1; SMN2POLBMAPTNPC1 | |
| SCHEMBL2635495 | 0.64 | NPC1 (0.48) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB | |
| SCHEMBL2636032 | 0.64 | POLB (0.44) | TRPM4SMN1; SMN2CYP1A2CYP2C19POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438037-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139481-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | claimed |
| EP-2438037-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139481-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |