Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.79 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.69 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.69 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.69 |
| ▸ | CDC25A | P30304 | 3/20 | 0.60 |
| ▸ | CDC25C | P30307 | 3/20 | 0.60 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263528 | 0.82 | CSNK2A2 (1.00) | ABCG2CSNK2A2CSNK2BCSNK2A1CDC25A | |
| SCHEMBL261654 | 0.70 | CSNK2A2 (0.76) | ABCG2CSNK2A2CSNK2BCSNK2A1CDC25A | |
| SCHEMBL21023182 | 0.68 | P2RX4 (0.53) | ABCG2CSNK2A2CSNK2BCSNK2A1P2RX4 | |
| SCHEMBL21167118 | 0.67 | P2RX4 (0.48) | ABCG2CSNK2A2CSNK2BCSNK2A1P2RX4 | |
| SCHEMBL5973866 | 0.63 | HDAC4 (0.48) | ABCG2CDC25ACDC25CALDH1A1MAPT | |
| SCHEMBL21953164 | 0.62 | P2RX4 (0.53) | CSNK2A2CSNK2BCSNK2A1P2RX4ALDH1A1 | |
| SCHEMBL29904927 | 0.62 | P2RX4 (1.00) | P2RX4ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL14160818 | 0.62 | P2RX4 (1.00) | P2RX4ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL17969634 | 0.61 | CYP19A1 (0.45) | P2RX4ALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL8985073 | 0.61 | GSK3B (0.67) | P2RX4ALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133913-B2 | Substituted indeno [1,2-b]indole derivatives as novel inhibitors of protein kinase CK2 and their use as tumor therapeutic agents, cytostatics and diagnostic aids | Heinrich-Heine Universitat Dusseldof (DE) | 2012-03-13 | — | — | US | disclosed |
| US-20100056599-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | HEINRICH-HEINE UNIVERSITAT DUSSELDORF (DE) | 2010-03-04 | — | — | US | disclosed |
| EP-2079691-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | Heinrich-Heine-Universität Düsseldorf (DE) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008040547-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOUR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | HEINRICH-HEINE UNIVERSITÄT DÜSSELDORF (DE) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056599-A1 | SUBSTITUTED INDENO[1,2-B]INDOLE DERIVATIVES AS NOVEL INHIBITORS OF PROTEIN KINASE CK2 AND THEIR USE AS TUMOR THERAPEUTIC AGENTS, CYTOSTATICS AND DIAGNOSTIC AIDS | CDK2, CSNK1A1, CDK1 | ABCG2 921/4885CSNK2A2 9/4885CSNK2B 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.